Ohio State vs. USC prediction: Short-handed Buckeyes face road trap as Trojans fight for season

Ohio State begins life without quarterback Julian Sayin as they travel to Los Angeles to face a desperate USC team. The Buckeyes, ranked among the nation's best, must navigate a hostile road environment while missing their key signal-caller. USC, wounded and backed into a corner after early-season struggles, sees this as a must-win to salvage their campaign. The odds and spread reflect a tight contest, with the Trojans potentially undervalued at home. For Ohio State, this game tests their depth and resilience; for USC, it's a chance to reset their season. Expect a physical, high-stakes matchup where turnovers and red-zone efficiency will decide the outcome. The Buckeyes' ability to adapt without Sayin could define their playoff trajectory.