GLP-1 Weight-Loss Drugs and Marathon Running: Expert Advice on Managing Side Effects

As GLP-1 weight-loss drugs like Ozempic and Wegovy gain popularity, some runners are grappling with challenging side effects during marathon training. Keri M., a marathoner in her 50s who has completed four full marathons and dozens of half marathons, knew her race would be terrible—but this time, it wasn't due to inexperience. The medication left her feeling 'so sick' during the event, highlighting a growing concern among endurance athletes. Experts say that while GLP-1s can aid weight loss, they may cause nausea, fatigue, and gastrointestinal distress, which can severely impact performance. Proper timing of doses, adjusted fueling strategies, and medical guidance are key for runners on these drugs. As more athletes turn to GLP-1s, understanding how to balance treatment with training is crucial for both safety and success.