Jimmy Fallon & Jamie Lee Curtis Channel Nathan Fielder and Elizabeth Holmes in Tonight Show Cold Open

On Wednesday's episode of The Tonight Show, host Jimmy Fallon and Oscar-winning actress Jamie Lee Curtis teamed up for a Halloween-themed cold open that parodied the hit series The Rehearsal and the Theranos scandal. Fallon impersonated comedian Nathan Fielder, while Curtis transformed into disgraced Theranos founder Elizabeth Holmes, complete with her signature black turtleneck and deep voice. The sketch saw Fallon-as-Fielder grilling Curtis-as-Holmes with his trademark deadpan awkwardness, asking pointed questions about her fraudulent blood-testing startup. The bit arrived just as Curtis has been promoting her latest film, Halloween Ends, and as Holmes began her 11-year prison sentence for defrauding investors. By blending two of the year's most talked-about cultural figures, the cold open gave viewers a timely, comedic take on tech hubris and media spectacle. The sketch is already generating buzz online, with fans praising both stars' uncanny impersonations. Expect more viral moments as late-night shows lean into Halloween and the year's biggest news stories.